反应详情

温度

100 °C

A solution of 220 mg (0.469 mmol, 72% pure) of 2,5-dimethyl-7-(3-methylbutoxy)pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester from Example 122A in 4 ml of dioxane was admixed with 2 ml of 2 N sodium hydroxide solution. The resulting mixture was stirred at 100° C. for 15 h. The solvent was removed under reduced pressure. The residue was admixed with acetonitrile (5 ml), followed by the dropwise addition of trifluoroacetic acid (2 ml). The resulting precipitate was filtered off and dried under reduced pressure, which gave 45 mg (28% of theory, 90% pure) of the target compound.

1. customThe solvent was removed under reduced pressure
2. additionfollowed by the dropwise addition of trifluoroacetic acid (2 ml)
3. filtrationThe resulting precipitate was filtered off
4. customdried under reduced pressure, which
5. customgave 45 mg (28% of theory, 90% pure) of the target compound