Sodium Hydroxide → 7-[(2,6-Difluorobenzyl)oxy]-2-methylpyrazolo[1,5-a]pyridine-3-carboxylic Acid

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Reaction Steps

A solution of 200 mg (0.228 mmol, 43% pure) of 7-[(2,6-difluorobenzyl)oxy]-2-methylpyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester from Example 129A in 3 ml of dioxane was admixed with 1 ml of 2 N sodium hydroxide solution. The resulting mixture was stirred at room temperature for 72 h. The solvent was drawn off under reduced pressure and the residue was purified by flash chromatography using a prepacked silica gel cartridge (eluent:dichloromethane-methanol 100:1 to 10:1), which gave 100 mg (77% of theory, 61% pure) of the target compound.

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