反应详情

温度

0 °C

A stirred solution of 300 mg (3.48 mmol) of 2,4-difluoro-3-formylbenzonitrile (CAS 149489-14-5) in 10 ml of ethanol at 0° C. was admixed with 34 mg (0.89 mmol) of sodium borohydride in portions. After stirring at 0° C. for 1 h, the reaction mixture was mixed with water and extracted three times with methyl tert-butyl ether. The combined organic extracts were washed with water and saturated aqueous sodium chloride solution, and dried with a phase separation cartridge. The solvent was drawn off to dryness under reduced pressure, which gave 280 mg (82% of theory) of the target compound.

1. customat 0° C.
2. extractionextracted three times with methyl tert-butyl ether
3. washThe combined organic extracts were washed with water and saturated aqueous sodium chloride solution
4. customdried with a phase separation cartridge
5. customgave 280 mg (82% of theory) of the target compound