反应详情

温度

100 °C

A solution of 390 mg (1.13 mmol) of 7-benzyloxy-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester (Example 7A) in 6 ml of 1,4-dioxane was admixed with 4 ml of 2 M sodium hydroxide solution. The mixture was stirred at 100° C. for a further 18 hours. The reaction mixture was cooled under reduced pressure and then concentrated under reduced pressure. The residue was admixed with acetonitrile (10 ml) and water (2 ml), followed by 2 ml of trifluoroacetic acid, which was added dropwise. The resulting precipitate was filtered off and dried under reduced pressure, which gave 262 mg (72% yield, 92% pure) of the target compound.

1. temperatureThe reaction mixture was cooled under reduced pressure
2. concentrationconcentrated under reduced pressure
3. additionwas added dropwise
4. filtrationThe resulting precipitate was filtered off
5. customdried under reduced pressure, which
6. customgave 262 mg (72% yield, 92% pure) of the target compound