Cyclohexene → HCID 178444850, compound

HRID 1486307Notes

Reaction equation

HRID 1486307 reaction equation
[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]([CH3:35])([CH2:32][CH2:33][CH3:34])[CH2:9][NH:10][C:11]([C:13]1[C:14]([CH3:31])=[N:15][N:16]2[C:21]([O:22]CC3C=CC=CC=3)=[CH:20][C:19]([CH3:30])=[CH:18][C:17]=12)=[O:12])([CH3:4])([CH3:3])[CH3:2].C1CCCCC=1>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]([CH3:35])([CH2:32][CH2:33][CH3:34])[CH2:9][NH:10][C:11]([C:13]1[C:14]([CH3:31])=[N:15][N:16]2[C:21]([OH:22])=[CH:20][C:19]([CH3:30])=[CH:18][C:17]=12)=[O:12])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 8079CyclohexeneHCID 117864691rac-[1-({[7-(Benzyloxy)-2,5-dimethylpyrazolo[1,5-a]pyridin-3-yl]carbonyl}amino)-2-methylpentan-2-yl]carbamic Acid tert-butyl Ester

Product 1

HCID 178444850HCID 178444850, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 207 mg (0.418 mmol) of rac-[1-{[7-benzyloxy-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carbonyl]amino}methyl}-1-methylbutyl)carbamic acid tert-butyl ester (Example 140A) in 6 ml of absolute ethanol was admixed with 47 mg of palladium on charcoal (loading 10% by weight, activated) and 1.3 ml of cyclohexene. The reaction mixture was heated to reflux under an argon atmosphere for 2.5 hours. The resulting mixture was cooled to room temperature, filtered through a layer of Celite and concentrated under reduced pressure, which gave 206 mg (99% yield, 81% pure) of the target compound.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux under an argon atmosphere for 2.5 hours
  3. filtrationfiltered through a layer of Celite
  4. concentrationconcentrated under reduced pressure, which
  5. customgave 206 mg (99% yield, 81% pure) of the target compound

Sources & evidence

ORD record
ord-a21c163a81fb46e8a07af5165eeb253c
Source dataset
uspto-grants-2016_08
Patent number
US09422285B2

Reaction notes

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