反应详情

61.0 g (212.98 mmol) of rac-tert-butyl (2-cyanopentan-2-yl)carbamate-2-methylpropan-2-ol from Example 151A were dissolved in 618 ml of 7 N ammoniacal methanol and admixed under argon with 66 g of Raney nickel (50% aqueous slurry). Subsequently, the reaction mixture was hydrogenated in an autoclave at 20-30 bar overnight. The reaction mixture was filtered through Celite, rinsed well with methanol and concentrated. 43.70 g (95% of theory) of the target compound were obtained.

1. customwas hydrogenated in an autoclave at 20-30 bar overnight
2. filtrationThe reaction mixture was filtered through Celite
3. washrinsed well with methanol
4. concentrationconcentrated
5. custom43.70 g (95% of theory) of the target compound were obtained