Water → HCID 117864562, compound

Participants

Reaction Steps

A solution of 3.99 g (6.15 mmol, 72% purity) of 1-amino-2-[(2,6-difluorobenzyl)oxy]-4-methoxypyridinium 2,4,6-trimethylbenzenesulphonate (Example 161A) in 70 ml of N,N-dimethylformamide was admixed with 1.38 g (12.31 mmol) of ethyl 2-butynoate (CAS: 4341-76-8) and 2.55 g (18.46 mmol) of potassium carbonate. The reaction mixture was stirred at room temperature for 18 hours and added dropwise to 150 ml of water. The resulting precipitate was filtered off and dried under reduced pressure, which gave 477 mg (12% yield, 57% purity) of product.

Provenance & Evidence