反应详情

温度

100 °C

A solution of 375 mg (0.57 mmol, 57% purity) of 7-[(2,6-difluorobenzyl)oxy]-5-methoxy-2-methylpyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester (Example 162A) in 8.0 ml of 1,4-dioxane was admixed with 6.0 ml of aqueous 2M sodium hydroxide solution. The mixture was stirred at 100° C. for a further 18 hours. The reaction mixture was concentrated under reduced pressure. The residue was admixed with 4 ml of acetonitrile and 2 ml of water, followed by 0.8 ml of trifluoroacetic acid. The resulting precipitate was filtered off and dried under reduced pressure, which gave 172 mg (65% yield, 75% purity) of product.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. filtrationThe resulting precipitate was filtered off
3. customdried under reduced pressure, which
4. customgave 172 mg (65% yield, 75% purity) of product