Potassium Carbonate → HCID 117864695, compound

Participants

Reaction Steps

A solution of 1.88 g (1.54 mmol, 38% purity) of 1-amino-2-[(2,6-difluorobenzyl)oxy]-4-ethylpyridinium 2,4,6-trimethylbenzenesulphonate (Example 166A) in 12 ml of N,N-Dimethylformamide was admixed with 0.35 g (3.08 mmol) of ethyl 2-butynoate (CAS: 4341-76-8) and 0.64 g (4.61 mmol) of potassium carbonate. The reaction mixture was stirred at room temperature for 3 hours. The solvent was concentrated and the residue was partitioned between water and ethyl acetate. The organic phase was removed, washed with aqueous sodium chloride solution and concentrated under reduced pressure. The residue was purified by flash chromatography using a prepacked silica gel cartridge (eluent:cyclohexane/ethyl acetate, gradient 0% to 10%), which gave 0.29 g (35% yield, 70% purity) of product.

Provenance & Evidence