Sodium Hydroxide → HCID 117859562, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 287 mg (0.54 mmol, 70% purity) of 7-[(2,6-difluorobenzyl)oxy]-5-ethyl-2-methylpyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester (Example 167A) in 5.5 ml of 1,4-dioxane was admixed with 2.7 ml of aqueous 2M sodium hydroxide solution. The mixture was stirred at 90° C. for a further 18 hours. The reaction mixture was concentrated under reduced pressure. The residue was admixed with water and the pH was adjusted to 7. The resulting precipitate was filtered off and dried under reduced pressure, which gave 280 mg (35% yield, 23% purity) of product, which were used in the next step without purification.

Provenance & Evidence