Trifluoroacetic acid → rac-N-(2-Amino-2-methylpentyl)-7-[(2,3-difluorobenzyl)oxy]-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxamide

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Reaction Steps

A solution of 35 mg (0.066 mmol) of rac-{1-[({7-[(2,3-difluorobenzyl)oxy]-2,5-dimethylpyrazolo[1,5-a]pyridin-3-yl}carbonyl)amino]-2-methylpentan-2-yl}carbamic acid tert-butyl ester (Example 118A) in 2 ml of dichloromethane was admixed with 0.079 ml (1.03 mmol) of trifluoroacetic acid. The resulting solution was stirred at room temperature overnight. The solvent was drawn off under reduced pressure and the residue was purified by preparative HPLC chromatography (Method 21), which gave 6 mg (27% of theory) of the target compound.

Provenance & Evidence