Trifluoroacetic acid → rac-N-(2-Amino-2-methylpentyl)-7-(cyclohexylmethoxy)-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxamide

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Reaction Steps

A solution of 40 mg (0.047 mmol, 59% pure) of rac-[1-({[7-(cyclohexylmethoxy)-2,5-dimethylpyrazolo[1,5-a]pyridin-3-yl]carbonyl}amino)-2-methylpentan-2-yl]carbamic acid tert-butyl ester (Example 121A) in 2 ml of dichloromethane was admixed with 0.072 ml (0.94 mmol) of trifluoroacetic acid. The resulting solution was stirred at room temperature overnight. After the reaction had ended, the solvent was drawn off under reduced pressure and the residue was purified by preparative HPLC chromatography (Method 21), which gave 8 mg (43% of theory) of the target compound.

Provenance & Evidence