Trifluoroacetic acid → rac-N-(2-Amino-2-methylpentyl)-7-[(2,6-difluorobenzyl)oxy]-2-methylpyrazolo[1,5-a]pyridine-3-carboxamide

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Reaction Steps

A solution of 45 mg (0.046 mmol, 53% pure) of rac-{1-[({7-[(2,6-difluorobenzyl)oxy]-2-methylpyrazolo[1,5-a]pyridin-3-yl}carbonyl)amino]-2-methylpentan-2-yl}carbamic acid tert-butyl ester (Example 131A) in 4 ml of dichloromethane was admixed with 0.5 ml (6.49 mmol) of trifluoroacetic acid. The resulting solution was stirred at room temperature for 2 h. The solvent was drawn off under reduced pressure and the residue was purified by preparative HPLC chromatography (Method 21), which gave 6.5 mg (34% yield) of the target compound as a white powder.

Provenance & Evidence