Trifluoroacetic acid → HCID 117864715, compound

Participants

Reaction Steps

A solution of 118 mg (0.157 mmol, 73% purity) of rac-{1-[({7-[(2,6-difluorobenzyl)oxy]-5-methoxy-2-methylpyrazolo[1,5-a]pyridin-3-yl}carbonyl)amino]-2-methylpentan-2-yl}carbamic acid tert-butyl ester (Example 164A) in 12 ml of dichloromethane was admixed with 1.5 ml of trifluoroacetic acid. The resulting mixture was stirred at room temperature for two hours. The reaction mixture was concentrated under reduced pressure and the remaining residue was purified by preparative HPLC chromatography (Method 21), which gave 37 mg (53% yield) of product.

Provenance & Evidence