Trifluoroacetic acid → HCID 117864667, compound

Participants

Reaction Steps

A solution of 19 mg (0.033 mmol, 95% purity) of rac-{1-[({7-[(2,6-difluorobenzyl)oxy]-5-ethyl-2-methylpyrazolo[1,5-a]pyridin-3-yl}carbonyl)amino]-2-methylpentan-2-yl}carbamic acid tert-butyl ester (Example 169A) in 1 ml of dichloromethane was admixed with 0.15 ml of trifluoroacetic acid. The resulting mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure and the remaining residue was purified by preparative HPLC chromatography (Method 21), which gave 4.5 mg (15% yield) of product.

Provenance & Evidence