5-Chloro-2-formylphenylboronic acid → 4-Chloro-2-formylphenylboronic Acid (contains varying amounts of Anhydride)

HRID 1486423Notes

Reaction equation

HRID 1486423 reaction equation
[Cl:1]C1C=CC2C3=C(C4CCCCC4)C4C=CC(C(OC(C)(C)C)=O)=CC=4N3CC(C(OC)=O)=CC=2C=1.Cl[C:38]1[CH:39]=[CH:40][C:41]([CH:47]=[O:48])=[C:42]([B:44]([OH:46])[OH:45])[CH:43]=1>>[Cl:1][C:39]1[CH:38]=[CH:43][C:42]([B:44]([OH:46])[OH:45])=[C:41]([CH:47]=[O:48])[CH:40]=1

Participants

3

Reactant 2

HCID 38069525-Chloro-2-formylphenylboronic acidHCID 58244852HCID 58244852, compound

Product 1

HCID 237304254-Chloro-2-formylphenylboronic Acid (contains varying amounts of Anhydride)Yield 70%

Procedure

The title compound 24a was synthesized following the 2-step procedure reported for the synthesis of 10-tert-butyl 6-methyl 3-chloro-13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylate 21a, using 5-chloro-2-formylphenylboronic acid in the first step, instead of 4-chloro-2-formylphenylboronic acid 34a, and was obtained with an overall yield of 70% as a yellowish solid; m/z 507 [M+H]+.

Sources & evidence

ORD record
ord-38e5239fe34d4e88a6697eaa90dc0395
Source dataset
uspto-grants-2016_08
Patent number
US09427440B2

Reaction notes

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