Chlorobenzene → Enclomiphene

Participants

Reaction Steps

A round bottomed flask with standard equipment was loaded with 14.7 g of clomiphene citrate, 50 mL of chlorobenzene and 50 mL of water. Into the flask, 8 mL of aqueous sodium hydroxide 30% w/w were dropped, up to pH 12. The reaction mixture was stirred, the layers were separated, the organic phase was washed with 3 x 20 mL of water and treated with sodium sulfate, obtaining a clear solution of Clomiphene in chlorobenzene.

Provenance & Evidence