反应详情

cis-4-[(tert-Butoxycarbonyl)aminomethyl]cyclohexyl-4-nitrobenzoate (4.81 g, 12.7 mmol) was dissolved in methanol (345 mL) and sodium hydroxide (10.17 g, 254.2 mmol) was added. After 20 hours at room temperature, methanol was removed under vacuum. The residue was taken up in water and extracted with ethyl acetate. After drying the organic phase over sodium sulphate, and removing the drying agent and solvent residues under vacuum, the product was obtained at 88% yield (2.57 g), and was used without purification in the next reaction.

1. custommethanol was removed under vacuum
2. extractionextracted with ethyl acetate
3. dry with materialAfter drying the organic phase over sodium sulphate
4. customremoving the drying agent and solvent residues under vacuum
5. customthe product was obtained at 88% yield (2.57 g)
6. customwas used without purification in the next reaction