HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoic Acid → HCID 178523391, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoic Acid | HCID 9973 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 178511283 | HCID 178511283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178523391 | HCID 178523391 | 71% |
Reaction Steps
{trans-4-[(8-Fluoroquinolin-4-yl)oxy]cyclohexyl}methylamine (1.82 g mg, 6.63 mmol) was dissolved in tetrahydrofuran (415 mL). After adding HATU (2.78 g, 7.30 mmol), diisopropylethylamine (1.30 mL, 7.30 mmol) and 4-fluorobenzoic acid (1.02 g, 7.30 mmol), the reaction mixture was stirred overnight at room temperature. After chromatography, the desired product was obtained at 71% yield (1.96 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428460B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-688bf87b034d43a08620b2377acf64f3 |
| Source note | uspto-grants-2016_08 |