Water → HCID 178523803, compound

Participants

Reaction Steps

trans-4-(4-Quinolyloxy)cyclohexylamine (400 mg, 1.65 mmol) was put in pyridine (12 mL) and catalytic amounts of triethylamine were added. At 0° C., 3,4-difluorobenzoyl chloride (291 mg, 1.65 mmol) was added. Then the reaction mixture was stirred at room temperature overnight. Water was added, and the precipitate was filtered off with suction. After drying, the desired product was obtained at 96% yield (610 mg).

Provenance & Evidence