HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Dehydro Tolvaptan → Tolvaptan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Dehydro Tolvaptan | HCID 11362843 | — |
| Solvent | Water | HCID 962 | — |
| Product | Tolvaptan | HCID 216237 | — |
Reaction Steps
In a preferred embodiment of the present invention, starting material 7-chloro-1-[2-methyl-4-(2-methylbenzoylamino) benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine of Formula 2 is reduced using hydrogenating agent in a solvent mixture containing alcohol and water to obtain Tolvaptan of Formula 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428461B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-ad785b99425d449db216b668d33c6312 |
| Source note | uspto-grants-2016_08 |