HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1486500Generated: October 29, 2026
Methanesulfonyl chloride → 5-Methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester
https://huagongshe.com/reaction/1486500
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 5-Hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester | HCID 57990210 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester | HCID 57990212 | — |
Reaction Steps
To a cooled solution (5° C.) of 5-hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester (11 Kg, 38.8 mol, step 7) and Et-3N (7.04 L, 50.6 mol) in DCM (55 L) was added methanesulphonyl chloride (2.97 L, 38.4 mol) so that the internal temp <10° C. After stirring for 0.5 h at 5° C. the solution was used below in step 9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09428439B2 |
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| Source dataset | uspto-grants-2016_08 |
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| ORD ID | ord-d3703db664fb4bd597ee6a11d14ccab5 |
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| Source note | uspto-grants-2016_08 |
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