Water → HCID 117653243, compound

Participants

Reaction Steps

Compound 5 (50.0 mg, 0.1066 mmol) was dissolved in THF (1.0 mL) and H2O (0.5 mL) and LiOH.H2O (9.0 mg, 0.2133 mmol, 2.0 equiv.) was added. After stirring for 2 h, the reaction was quenched by the addition of sat. aq. NH4Cl solution and diluted with H2O. The resulting mixture was extracted with EtOAc (×3), and the combined organic phases were dried over MgSO4 and concentrated in vacuo. The crude residue was purified by preparative tlc (1:5:94 AcOH/MeOH/CH2Cl2) to afford the title acid 6 (31.4 mg, 67%)

Provenance & Evidence