HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 117653526, compound → HCID 117653620, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 117653526 | HCID 117653526 | — |
| Reactant | HCID 117653645 | HCID 117653645 | — |
| Reactant | HCID 178461630 | HCID 178461630 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 117653620 | HCID 117653620 | 59% |
Reaction Steps
The title compound 13 was prepared from compound 4 (91.2 mg, 0.2128 mmol) and EtMgBr (227 μL of a 3.0 M solution in Et2O, 0.681 mmol, 3.2 equiv.) following the same procedure as that for compound 12. Purification by column chromatography (1:10:90→2:15:85 AcOH/EtOAc/CH2Cl2) afforded the title compound 13 (55.2 mg, 59%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428447B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-af9d0ad5a4bb455da21d837fcc28dfbc |
| Source note | uspto-grants-2016_08 |