Triethylamine → HCID 75202496, compound

Participants

Reaction Steps

In a round bottom flask, 7,7-dimethyl-5,6,7,8-tetrahydronaphthalen-1-amine (150 mg, 0.86 mmol, 1.0 eq.) was dissolved in 5 ml of THF. Triethylamine (0.104 mg, 1.02 mmol, 1.2 eq) was added followed by a solution of 2-(difluoromethyl)nicotinoyl chloride (180 mg, 0.94 mmol, 1.1 eq) in 1 ml of THF. Stirring was allowed for 2 h at r.t. The reaction was quenched with water, the organic layer extracted with AcOEt, washed with brine and dried over chemelut cartridge. The solvent was removed under vacuum and purification of the crude material by

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