Methyl iodide → HCID 118023135, compound

Participants

Reaction Steps

The title compound was obtained according to the procedure described for Example 16 (Step 1), starting from tert-butyl 5-bromo-2,4-dioxo-pyrimidine-1-carboxylate (1.43 g, 4.92 mmol); iodomethane was used herein and the reaction was stirred under nitrogen for 1.5 hrs. The crude was purified by column chromatography using a Teledyne ISCO apparatus (cyclohexane:EtOAc 70:30) to afford the title compound (0.85 g, 57%) as a white solid. 1H NMR (400 MHz, CDCl3): δ 1.62 (s, 9H), 3.40 (s, 3H), 8.18 (s, 1H).

Provenance & Evidence