Hydrazine → HCID 178509282, compound

HRID 1486563Notes

Reaction equation

HRID 1486563 reaction equation
[C:1](/[N:3]=[C:4](\SC)/[NH:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:8]([Cl:13])[CH:7]=1)#[N:2].[NH2:16][NH2:17]>C(O)C>[NH2:2][C:1]1[N:3]=[C:4]([NH:5][C:6]2[CH:11]=[C:10]([Cl:12])[CH:9]=[C:8]([Cl:13])[CH:7]=2)[NH:17][N:16]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 178503892HCID 178503892, compound

Product 1

HCID 178509282HCID 178509282, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of (Z)-methyl N′-cyano-N-(3,5-dichlorophenyl)carbamimidothioate (8 g, 30.8 mmol) and hydrazine (9.85 g, 9.65 ml, 308 mmol) in Ethanol (120 ml) was stirred at 70° C. for 3 h. It was concentrated to a small volume and water was added to give a suspension. The suspension was filtered, washed with water to give a white solid as desired product (7.44 g, 99% yield). MS +m/z: 244.0 (M+H)+

Workup

  1. concentrationIt was concentrated to a small volume and water
  2. additionwas added
  3. customto give a suspension
  4. filtrationThe suspension was filtered
  5. washwashed with water

Sources & evidence

ORD record
ord-0ff4e20a2a8e4745893ffa346266bc0c
Source dataset
uspto-grants-2016_08
Patent number
US09428469B2

Reaction notes

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