Acetic Acid → HCID 178509836, compound

Participants

Reaction Steps

To a solution of N3-(3,5-dichlorophenyl)-1H-1,2,4-triazole-3,5-diamine Intermediate 2 (100 mg, 410 μmol) in MeOH (3.5 mL) was added 4-formylbenzonitrile (53.7 mg, 410 μmol) followed by acetic acid (36.7 mg, 35 μl, 611 μmol). The reaction was stirred at room temperature for 15 minutes, 2-picoline borane complex (52.6 mg, 492 μmol) was added and the stirring was continued overnight. The reaction mixture was poured into 0.1N HCl solution (25 ml). The volume was reduced and the resulting suspension was filtered to give an off white solid as desired product (109 mg, 67% yield). MS +m/z: 358 (M+H)+

Provenance & Evidence