Acetic Acid → HCID 178486138, compound

Participants

Reaction Steps

To a solution of N3-(3,5-dichlorophenyl)-1H-1,2,4-triazole-3,5-diamine Intermediate 2 (100 mg, 410 μmol) in MeOH (5 mL) was added 4-formyl-N,N-dimethyl-benzenesulfonamide (96.1 mg, 451 μmol) followed by acetic acid (36.7 mg, 35 μl, 611 μmol). The reaction was stirred at room temperature for 15 minutes, 2-picoline borane complex (65.7 mg, 615 μmol) was added and the stirring was continued for 5 days. The reaction mixture was poured into 0.1N HCl solution (25 ml) to give a suspension, and the suspension was filtered to give an off white solid as desired product (119 mg, 66% yield). MS +m/z: 441 (M+H)+

Provenance & Evidence