Acetic Acid → HCID 178527355, compound

Participants

Reaction Steps

To a solution of N3-(3,5-dichlorophenyl)-1H-1,2,4-triazole-3,5-diamine Intermediate 2 (100 mg, 410 μmol) in MeOH (3.5 ml) was added 4-(pyrrolidin-1-ylsulfonyl)benzaldehyde (118 mg, 492 μmol) followed by acetic acid (36.7 mg, 35 μl, 611 μmol). The reaction was stirred at room temperature for 15 minutes, 2-picoline borane complex (65.7 mg, 615 μmol) was added and the stirring was continued for 6 days. The reaction mixture was poured into 0.1N HCl solution (25 ml) to give a suspension, which was filtered to give a white solid as desired product (151 mg, 79% yield). MS +m/z: 467 (M+H)+

Provenance & Evidence