Sodium Hydroxide → HCID 72188729, compound

Participants

Reaction Steps

Compound 3 (0.84 g, 3 mmol) was dissolved in methanol (40 mL), and a 1 mol/L aqueous sodium hydroxide solution (4 mL, NaOH 4 mmol) was added thereto at room temperature, and the mixture was stirred for 20 hours. The solvent was distilled off under a reduced pressure, and the residue was then dissolved in water, and a 10% aqueous citric acid solution was added thereto to adjust its pH to about 4. The liquid mixture was extracted with dichloromethane, an organic layer was washed with water and saturated sodium chloride solution, and the washed extract was then dried over anhydrous sodium sulfate, to give an intended compound (0.72 g, 90%) in the form of a colorless oily substance.

Provenance & Evidence