HCID 86667925, compound → HCID 67085815, compound

Participants

Reaction Steps

To a solution of methyl 5-(2,2,2-trifluoro-1-(methylsulfonyloxy)ethyl)picolinate (95 mg, 0.3 mmol) in 5 mL of MeOH was added 10% Pd/C (45 mg). Hydrogenation with 1 atm H2 was carried out at room temperature for 2 h. After the catalyst was removed by filtration, the filtrated was concentrated. The residue was dissolved in DCM and washed with sat. NaHCO3 (aq,), and brine. The solution was dried (MgSO4) and concentrated to give methyl 5-(2,2,2-trifluoroethyl)picolinate that was used without purification.

Provenance & Evidence