1-Chloroethyl 2-methylpropanoate → (1S,2S,3S,5R,6S)-3'-allyl 6-(1-(isobutyryloxy)ethyl) 3-fluoro-5'-oxospiro[bicyclo[3.1.0]hexan-2,4'-oxazolidine]-3',6-dicarboxylate

HRID 1486673Notes

Reaction equation

HRID 1486673 reaction equation
[CH2:1]([O:4][C:5]([N:7]1[C@:11]2([C@@H:16]([F:17])[CH2:15][C@@H:14]3[C@H:12]2[C@H:13]3[C:18]([OH:20])=[O:19])[C:10](=[O:21])[O:9][CH2:8]1)=[O:6])[CH:2]=[CH2:3].[C:22]([O:27][CH:28](Cl)[CH3:29])(=[O:26])[CH:23]([CH3:25])[CH3:24]>>[F:17][C@@H:16]1[C@@:11]2([C:10](=[O:21])[O:9][CH2:8][N:7]2[C:5]([O:4][CH2:1][CH:2]=[CH2:3])=[O:6])[CH:12]2[C@H:14]([C@@H:13]2[C:18]([O:20][C@H:28]([O:27][C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])[CH3:29])=[O:19])[CH2:15]1

Participants

3

Reactant 2

HCID 131387431-Chloroethyl 2-methylpropanoateHCID 117987522(1S,2S,3S,5R,6S)-3'-((allyloxy)carbonyl)-3-fluoro-5'-oxospiro[bicyclo[3.1.0]hexan-2,4'-oxazolidine]-6-carboxylic acid

Product 1

HCID 131736792(1S,2S,3S,5R,6S)-3'-allyl 6-(1-(isobutyryloxy)ethyl) 3-fluoro-5'-oxospiro[bicyclo[3.1.0]hexan-2,4'-oxazolidine]-3',6-dicarboxylateYield 15.5%

Procedure

(1S,2S,3S,5R,6S)-3′-((Allyloxy)carbonyl)-3-fluoro-5′-oxospiro[bicyclo[3.1.0]hexan-2,4′-oxazolidine]-6-carboxylic acid (A-1-2, 1.43 g) and 1-chloroethyl isobutyrate (1.80 g) were treated in the same manner as in Example A-1 (3) to give (1S,2S,3S,5R,6S)-3′-allyl 6-(1-(isobutyryloxy)ethyl) 3-fluoro-5′-oxospiro[bicyclo[3.1.0]hexan-2,4′-oxazolidine]-3′,6-dicarboxylate (A-8-1, 307 mg) as a pale yellow oil.

Sources & evidence

ORD record
ord-af15bd1336154e138392f56c7a6bcf97
Source dataset
uspto-grants-2016_08
Patent number
US09428483B2

Reaction notes

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