1-Chloroethyl Cyclohexyl Carbonate → (1S,2S,3S,5R,6S)-2-amino-6-((1-(((cyclohexyloxy)carbonyl)oxy)ethoxy)carbonyl)-3-fluorobicyclo[3.1.0]hexane-2-carboxylic acid

Participants

Reaction Steps

(1S,2S,3S,5R,6S)-3′-((Allyloxy)carbonyl)-3-fluoro-5′-oxospiro[bicyclo[3.1.0]hexan-2,4′-oxazolidine]-6-carboxylic acid (A-1-2, 1.35 g) and 1-chloroethyl cyclohexyl carbonate (2.06 mL) were treated in the same manner as in Example A-1 (3) and (4) to give the title compound (A-10, 113 mg) as a colorless solid.

Provenance & Evidence