1(3H)-Isobenzofuranone, 3-bromo- → HCID 131736793, compound

Participants

Reaction Steps

(1S,2S,3S,5R,6S)-3′-((Allyloxy)carbonyl)-3-fluoro-5′-oxospiro[bicyclo[3.1.0]hexan-2,4′-oxazolidine]-6-carboxylic acid (A-1-2, 640 mg) and 3-bromophthalide (456 mg) were treated in the same manner as in Example A-1 (3) to give (1S,2S,3S,5R,6S)-3′-allyl 6-(3-oxo-1,3-dihydroisobenzofuran-1-yl) 3-fluoro-5′-oxospiro[bicyclo[3.1.0]hexan-2,4′-oxazolidine]-3′,6-dicarboxylate (A-17-1, 380 mg) as a pale yellow amorphous.

Provenance & Evidence