HCID 117987479, compound → HCID 72550767, compound

Participants

Reaction Steps

To a suspension of (1S,2S,3S,5R,6S)-2-amino-3-fluoro-6-(((S)-1-(((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)carbonyl)oxy)ethoxy)carbonyl)bicyclo[3.1.0]hexane-2-carboxylic acid benzenesulfonate obtained in Step (4) (A-18-4, 33.0 g) in acetone (125 mL), water (25 mL) was added for dissolution. The resulting solution was added dropwise to water (1225 mL) over 30 minutes and the mixture was stirred at room temperature for 2 hours. The resulting solid was collected by filtration and washed with water (50 ml) to give the title compound (A-18, 24.08 g) as a colorless solid.

Provenance & Evidence