1-Chloroethyl Cyclohexyl Carbonate → HCID 117987604, compound

HRID 1486684Notes

Reaction equation

HRID 1486684 reaction equation
C([O:4][C:5]([C@@H:7]1[C@@H:12]2[C@H:8]1[CH2:9][C@H:10]([F:23])[C@@:11]2([NH:16]C(OCC=C)=O)[C:13]([OH:15])=[O:14])=[O:6])C=C.[C:24](=[O:36])([O:29][CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1)[O:25][CH:26](Cl)[CH3:27]>>[NH2:16][C@@:11]1([C:13]([O:15][CH:26]([O:25][C:24]([O:29][CH:30]2[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)=[O:36])[CH3:27])=[O:14])[C@@H:10]([F:23])[CH2:9][C@@H:8]2[C@H:12]1[C@H:7]2[C:5]([OH:4])=[O:6]

Participants

3

Reactant 2

HCID 112295291-Chloroethyl Cyclohexyl CarbonateHCID 117987603HCID 117987603, compound

Product 1

HCID 117987604HCID 117987604, compoundYield 14.4%

Procedure

(1S,2S,3S,5R,6S)-6-((Allyloxy)carbonyl) 2-(((allyloxy)carbonyl)amino)-3-fluorobicyclo[3.1.0]hexane-2-carboxylic acid (B-1-1, 701 mg) and 1-chloroethyl cyclohexyl carbonate (664 mg) were treated in the same manner as in Example A-8 (1), (2) to give the title compound (B-1, 115 mg) as a yellow solid.

Sources & evidence

ORD record
ord-65eabd274df84dfb8f7a44aef6b902de
Source dataset
uspto-grants-2016_08
Patent number
US09428483B2

Reaction notes

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