Hydrochloric Acid → 1-(3-Amino-benzyl)-piperidine-4-carboxylic acid cyclohexylamide

Participants

Reaction Conditions

Reaction Steps

A solution of [3-(4-cyclohexylcarbamoyl-piperidin-1-ylmethyl)-phenyl]-carbamic acid tert-butyl ester (4.6 g, 11.1 mmol) in 1,4-dioxane (110 mL) is cooled down to 0° C. and treated with a 4N HCl solution in 1,4-dioxane (24.9 mL, 99.6 mmol). The reaction mixture is heated to 60° C. for 1 h. The reaction mixture is cooled down to RT and treated with aqueous 2N sodium hydroxide. After evaporation of 1,4-dioxane under reduced pressure the reaction mixture is extracted twice with DCM (110 mL). The combined organic phases are dried over MgSO4 and evaporated to yield the title compound as a yellowish powder: LC-MS A: tR=0.50 min; [M+H]+=316.32.

Provenance & Evidence