Ethylboronic acid → HCID 131736805, compound

Participants

Reaction Steps

The title compound is prepared according to the reactions described above starting from 2-bromo-5-nitro-benzaldehyde and piperidine-4-carboxylic acid tert-butylamide yielding after reductive amination 1-(2-bromo-5-nitro-benzyl)-piperidine-4-carboxylic acid tert-butylamide; LC-MS A: tR=0.62 min; [M+H]+=397.99; followed by alkylation with ethylboronic acid yielding 1-(2-ethyl-5-nitro-benzyl)-piperidine-4-carboxylic acid tert-butylamide; LC-MS A: tR=0.66 min; [M+H]+=348.34, followed by reduction with stannous chloride the title compound; LC-MS A: tR=0.49 min; [M+H]+=318.21.

Provenance & Evidence