Hydrochloric Acid → [3-(4-Chloro-benzoylamino)-benzyl]-piperidine-4-carboxylic acid

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Reaction Steps

A solution of 1-[3-(4-chloro-benzoylamino)-benzyl]-piperidine-4-carboxylic acid ethyl ester (1.65 g, 4.12 mmol) in a mixture of THF (20 mL) water (10 mL) and MeOH (10 mL) is treated with lithium hydroxide monohydrate (190 mg, 4.53 mmol) at RT for 2 h. Aq. 2N HCl (2.3 mL) is added and the resulting solution is lyophilized to yield the crude title compound (1.41 g) containing one equivalent LiCl. LC-MS A: tR=0.64 min; [M+H]+=372.93.

Provenance & Evidence