HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Chloro-4-fluorophenyl)acetyl chloride → rac-1-{3-[2-(2-Chloro-4-fluoro-phenyl)-acetylamino]-benzyl}-pyrrolidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Chloro-4-fluorophenyl)acetyl chloride | HCID 2757568 | — |
| Reactant | Methyl Pyrrolidine-3-carboxylate | HCID 4114360 | — |
| Reactant | 4-Chloro-N-(3-[1,3]dioxolan-2-yl-phenyl)-benzamide | HCID 86706547 | — |
| Reactant | 1-[3-(4-Chloro-benzoylamino)-benzyl]-piperidine-4-carboxylic acid ethyl ester | HCID 86706548 | — |
| Product | rac-1-{3-[2-(2-Chloro-4-fluoro-phenyl)-acetylamino]-benzyl}-pyrrolidine-3-carboxylic acid | HCID 131736811 | — |
Reaction Steps
The title compound is prepared according to the reaction sequence 2.001a-2.001d described above using 2-(2-chloro-4-fluorophenyl)acetyl chloride instead of 4-chlorobenzoyl chloride as in 2.001a and methyl pyrrolidine-3-carboxylate instead of ethyl isonipecotate as in 2.001c: LC-MS A: tR=0.63 min; [M+H]+=391.01.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428456B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-bfacaabcfc2345b89cbcb35fca2c9e04 |
| Source note | uspto-grants-2016_08 |