HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(Trifluoromethyl)pyridine-2-carbonyl chloride → rac-(2S*,4S*)-2-Methyl-1-{3-[(6-trifluoromethyl-pyridine-2-carbonyl)-amino]-benzyl}-piperidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(Trifluoromethyl)pyridine-2-carbonyl chloride | HCID 37863468 | — |
| Reactant | Methyl 2-methylpiperidine-4-carboxylate | HCID 75300498 | — |
| Reactant | 4-Chloro-N-(3-[1,3]dioxolan-2-yl-phenyl)-benzamide | HCID 86706547 | — |
| Reactant | 1-[3-(4-Chloro-benzoylamino)-benzyl]-piperidine-4-carboxylic acid ethyl ester | HCID 86706548 | — |
| Product | rac-(2S*,4S*)-2-Methyl-1-{3-[(6-trifluoromethyl-pyridine-2-carbonyl)-amino]-benzyl}-piperidine-4-carboxylic acid | HCID 131736813 | — |
Reaction Steps
The title compound is prepared according to the reaction sequence 2.001a-2.001d described above using 6-(trifluoromethyl)picolinoyl chloride instead of 4-chlorobenzoyl chloride as in 2.001a and rac-(2S*,4S*)-methyl 2-methylpiperidine-4-carboxylate instead of ethyl isonipecotate as in 2.001c: LC-MS A: tR=0.49 min; [M+H]+=368.07.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428456B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-0b553cb797d64df192d635900f23cb6a |
| Source note | uspto-grants-2016_08 |