HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methylnicotinoyl chloride → rac-(2S*,4S*)-2-Methyl-1-{3-[(5-methyl-pyridine-3-carbonyl)-amino]-benzyl}-piperidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methylnicotinoyl chloride | HCID 14538055 | — |
| Reactant | Methyl 2-methylpiperidine-4-carboxylate | HCID 75300498 | — |
| Reactant | 4-Chloro-N-(3-[1,3]dioxolan-2-yl-phenyl)-benzamide | HCID 86706547 | — |
| Reactant | 1-[3-(4-Chloro-benzoylamino)-benzyl]-piperidine-4-carboxylic acid ethyl ester | HCID 86706548 | — |
| Product | rac-(2S*,4S*)-2-Methyl-1-{3-[(5-methyl-pyridine-3-carbonyl)-amino]-benzyl}-piperidine-4-carboxylic acid | HCID 131736814 | — |
Reaction Steps
The title compound is prepared according to the reaction sequence 2.001a-2.001d described above using 5-methylnicotinoyl chloride instead of 4-chlorobenzoyl chloride as in 2.001a and rac-(2S*,4S*)-methyl 2-methylpiperidine-4-carboxylate instead of ethyl isonipecotate as in 2.001c: LC-MS A: tR=0.67 min; [M+H]+=422.08.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428456B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-1919b8e8ada1444dba6c05728cf22760 |
| Source note | uspto-grants-2016_08 |