HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → 4-Fluoro-piperidine-4-carboxylic acid tert-butylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | N-Cyclohexyl 1-boc-piperidine-4-carboxamide | HCID 4273089 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-fluoropiperidine-4-carboxylic Acid | HCID 21050397 | — |
| Product | 4-Fluoro-piperidine-4-carboxylic acid tert-butylamide | HCID 86706550 | — |
Reaction Steps
The title compound is prepared according to the reaction sequence 3.01a-2.01b described above using 1-(tert-butoxycarbonyl)-4-fluoropiperidine-4-carboxylic acid instead of 1-(tert-butoxycarbonyl)-piperidine-4-carboxylic acid and cyclopropylamine instead of cyclohexylamine as in 3.01a: LC-MS A: tR=0.41 min; [M+H]+=197.35.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428456B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-bef1bbd76f9244e8a58747773c974deb |
| Source note | uspto-grants-2016_08 |