5-Bromothiophene-3-carbaldehyde → HCID 86706555, compound

HRID 1486737Notes

Reaction equation

HRID 1486737 reaction equation
[Br:1][C:2]1[S:6][CH:5]=[C:4]([CH:7]=O)[CH:3]=1.Cl.[C:10]([NH:14][C:15]([CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:12])[CH3:11]>>[C:10]([NH:14][C:15]([CH:17]1[CH2:22][CH2:21][N:20]([CH2:7][C:4]2[CH:3]=[C:2]([Br:1])[S:6][CH:5]=2)[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:11])[CH3:12]

Participants

3

Reactant 2

HCID 122848945-Bromothiophene-3-carbaldehydeHCID 42943656HCID 42943656, compound

Product 1

HCID 86706555HCID 86706555, compound

Procedure

The title compound is prepared according to the reaction 3.01c described above using 5-bromo-thiophene-3-carbaldehyde and piperidine-4-carboxylic acid tert-butylamide hydrochloride as in 3.01c: LC-MS A: tR=0.64 min; [M+H]+=360.95.

Sources & evidence

ORD record
ord-a9912936093a4f6b93691b34958822f1
Source dataset
uspto-grants-2016_08
Patent number
US09428456B2

Reaction notes

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