4-Bromothiophene-2-carbaldehyde → HCID 86706556, compound

HRID 1486738Notes

Reaction equation

HRID 1486738 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=O)[S:5][CH:6]=1.Cl.[C:10]([NH:14][C:15]([CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:12])[CH3:11]>>[C:10]([NH:14][C:15]([CH:17]1[CH2:22][CH2:21][N:20]([CH2:7][C:4]2[S:5][CH:6]=[C:2]([Br:1])[CH:3]=2)[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:11])[CH3:12]

Participants

3

Reactant 2

HCID 877924-Bromothiophene-2-carbaldehydeHCID 42943656HCID 42943656, compound

Product 1

HCID 86706556HCID 86706556, compound

Procedure

The title compound is prepared according to the reaction 3.01c described above using 4-bromo-thiophene-2-carbaldehyde and piperidine-4-carboxylic acid tert-butylamide hydrochloride as in 3.01c: LC-MS A: tR=0.65 min; [M+H]+=360.95.

Sources & evidence

ORD record
ord-daf8c2c179e0463c92ba3141c720cc0a
Source dataset
uspto-grants-2016_08
Patent number
US09428456B2

Reaction notes

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