HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Amino-2-fluorophenyl)methanol → 6-Trifluoromethyl-pyridine-2-carboxylic acid (4-fluoro-3-formyl-phenyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Amino-2-fluorophenyl)methanol | HCID 2737680 | — |
| Reactant | 6-(Trifluoromethyl)pyridine-2-carbonyl chloride | HCID 37863468 | — |
| Reactant | N-(3-[1,3]Dioxolan-2-yl-phenyl)-5-methyl-nicotinamide | HCID 86706559 | — |
| Product | 6-Trifluoromethyl-pyridine-2-carboxylic acid (4-fluoro-3-formyl-phenyl)-amide | HCID 86706561 | — |
Reaction Steps
The title compound is prepared according to the reaction 4.01a described above using 6-(trifluoromethyl)picolinoyl chloride and (5-amino-2-fluorophenyl)methanol, followed by the oxidation of the alcohol intermediate 6-trifluoromethyl-pyridine-2-carboxylic acid (4-fluoro-3-hydroxymethyl-phenyl)-amide: LC-MS A: tR=0.80 min; [M+H]+=315.06.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428456B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-a416be6a75eb4aa491952da37a85dfe7 |
| Source note | uspto-grants-2016_08 |