Acetic Acid → 6-Methyl-pyridazine-4-carboxylic acid[3-(4-tert-butylcarbamoyl-piperidin-1-ylmethyl)-phenyl]-amide

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Reaction Steps

A solution of 3-chloro-6-methyl-pyridazine-4-carboxylic acid [3-(4-tert-butylcarbamoyl-piperidin-1-ylmethyl)-phenyl]-amide (53 mg, 0.119 mmol) in methanol (5 mL) is treated with palladium 10 wt % on activated carbon wet (50% water) (5.1 mg, 0.048 mmol, 0.4 eq) and AcOH (0.00683 ml, 0.119 mmol). The mixture is stirred under hydrogen atmosphere for 4 h. The suspension is filtered over celite and the solvent is evaporated. The residue is purified by prep HPLC E delivering the title compound (7 mg, 14%) as a light yellowish powder, LC-MS A: tR=0.58 min; [M+H]+=410.4.

Provenance & Evidence