Triethylamine → HCID 90157006, compound

Participants

Reaction Steps

To a solution of 3,3-difluoro-2-hydroxypropanamide (700 mg, 5.6 mmol) in DMF (5.6 mL) was added tert-butyldimethylchlorosilane (1.10 g, 7.28 mmol) and triethylamine (1.17 mL, 8.40 mmol). The mixture was stirred at room temperature for 3 h, diluted with ethyl acetate and washed with saturated aqueous sodium bicarbonate (2×) and brine. The organic layer was dried over sodium sulfate, filtered, and concentrated to provide Intermediate 10 that was used without further purification. MS: m/z=240.3 (M+H).

Provenance & Evidence