Ethanol → HCID 14324895, compound

Ethyl 4-(5-hydroxypentyl)piperazinecarboxylate (10.87 g, 65.09 mmol), 10% aqueous sodium hydroxide solution (150 mL) and ethanol (150 mL) were placed in a 500 mL round-bottomed flask, and heated under reflux with stirring overnight; the reaction system was cooled down to room temperature, and the solvent was distilled off under reduced pressure, to obtain a pale yellow oil; to the oil, 200 ml of saturated brine was added, followed by extraction with dichloromethane (5×200 mL); the resulting extract was dried with Na2SO4, filtered, and concentrated to obtain a pale yellow oil 9.69 g, yield 86.5% (which was directly used in the next step reaction).

1. temperatureheated
2. temperatureunder reflux
3. distillationthe solvent was distilled off under reduced pressure
4. customto obtain a pale yellow oil
5. extractionfollowed by extraction with dichloromethane (5×200 mL)
6. extractionthe resulting extract
7. dry with materialwas dried with Na2SO4
8. filtrationfiltered
9. concentrationconcentrated

ORD record

ord-f80d50f7da2b46d5a86aeaf9c80fcb3a

Source dataset

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09428496B2